The Effect of HPMC Concentration Variations on the Physical Properties of Semi-Polar Fraction Transdermal Patch Preparations from Kaempferia galanga L. Rhizomes
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Abstract
Background: Inflammation is a physiological response to infection or injury characterized by redness, swelling, and pain. Ethyl para-methoxycinnamate (EPMC), the major compound in Kaempferia galanga L., exhibits strong anti-inflammatory activity but has poor bioavailability when administered orally.
Objectives: This study aimed to evaluate the effect of Hydroxypropyl Methylcellulose (HPMC) concentration variations on the physical properties of transdermal patches containing semi-polar fractions of K. galanga rhizomes. Methods: Patches were prepared using HPMC concentrations of 0.5% (F1), 1.0% (F2), and 1.5% (F3). Physical characteristics including pH, water content, thickness, weight uniformity, and folding endurance were evaluated.
Results: Results showed that F3 exhibited the best physical properties: water content 3.77%, pH 6.88, thickness 0.305 mm, weight 0.7434 g, and folding endurance 364 times.
Conclusions and suggestions: All formulations met transdermal patch quality requirements. The F3 formulation demonstrated superior flexibility, stability, and mechanical strength, making it suitable for further pharmacological evaluation.
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