Evaluasi Karakteristik Fisik dan Stabilitas Emulsi Ekstrak Daun Kersen (Muntingia calabura L.) pada Berbagai Konsentrasi Ekstrak

Abstract View: 4,
Download: 2

Authors

  • Vella Lailli Damarwati Universitas Muhammadiyah Yogyakarta
  • Rosela Wati Universitas Muhammadiyah Yogyakarta
  • Risa Umari Yuli Aliviyanti Universitas Muhammadiyah Yogyakarta
  • Dyani Primasari Sukamdi Universitas Muhammadiyah Yogyakarta

DOI:

https://doi.org/10.32665/faskes.v4i1.6927

Keywords:

emulsi, ekstrak, Muntingia calabura L, karakteristik fisik, stabilitas

Abstract

Latar Belakang: Daun kersen (Muntingia calabura L.) diketahui mengandung
senyawa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi. Namun,
senyawa flavonoid memiliki stabilitas yang relatif rendah dan mudah mengalami
degradasi selama penyimpanan, sehingga diperlukan pengembangan dalam bentuk
sediaan, salah satunya emulsi. Tujuan: Penelitian ini bertujuan untuk mengevaluasi
karakteristik fisik dan stabilitas sediaan emulsi yang mengandung ekstrak etanol
daun kersen. Metode: Ekstrak daun kersen diperoleh melalui metode maserasi
menggunakan etanol 96% sebagai pelarut. Ekstrak kemudian diformulasikan ke
dalam sediaan emulsi dengan tiga variasi konsentrasi, yaitu F1 (0,1%), F2 (0,2%),
dan F3 (0,3% b/v). Karakteristik fisik sediaan dievaluasi melalui uji organoleptik,
homogenitas, viskositas, pH, daya lekat, dan tipe emulsi. Stabilitas fisik dievaluasi
menggunakan uji freeze-thaw dan sentrifugasi. Hasil: Seluruh formula
menghasilkan emulsi homogen, berwarna kuning hingga kuning pekat, beraroma
khas, bertekstur agak kental, dan bertipe minyak dalam air (M/A). Nilai pH berkisar
5,53–5,63 dan viskositas 5,32–7,96 cPs, dengan daya lekat <1 detik. Hasil uji
freeze-thaw dan sentrifugasi menunjukkan tidak terjadi pemisahan fase maupun
pembentukan partikel kasar. Setelah uji freeze-thaw, emulsi berubah menjadi putih
keruh dengan pH 5,55–5,70 dan viskositas 5,92–8,06 cPs. Kesimpulan: Emulsi
ekstrak daun kersen pada ketiga variasi konsentrasi memiliki karakteristik fisik dan
stabilitas yang baik. 

References

Adamovic, M., Adamovic, A., Barjaktarevic, A., Kostic, M., Kostic, O., Pecarski, D., Andjic, M.,

Dimitrijevic, J., Zivkovic, J., & Tomovic, M. (2026). Concentration-Dependent Rheological and

Sensory Effects of Walnut Leaf Extract in Cosmetic Emulsion Creams. Cosmetics, 13(1), 6.

https://doi.org/10.3390/cosmetics13010006

Andriana, A. N. I., Ishak, P., & Abasa, S. (2022). Formulasi Dan Uji Aktivitas Ekstrak Etanol Daun

Kersen (Muntingia Calabura) Sebagai Tabir Surya Pada Sediaan Gel Berdasarkan Nilai Sun

Protection Faktor (Spf). Pharmacology And Pharmacy Scientific Journals, 1(2), 75–83.

https://doi.org/10.51577/PAPSJOURNALS.V1I2.323

Baskar, V., Venkatesh, R., & Ramalingam, S. (2018). Flavonoids (antioxidants systems) in higher plants

and their response to stresses. In Antioxidants and Antioxidant Enzymes in Higher Plants (pp. 253–

. Springer International Publishing. https://doi.org/10.1007/978-3-319-75088-0_12

Budzianowska, A., Banaś, K., Budzianowski, J., & Kikowska, M. (2025). Antioxidants to Defend

Healthy and Youthful Skin—Current Trends and Future Directions in Cosmetology. Applied

Sciences (Switzerland), 15(5). https://doi.org/10.3390/app15052571

Chandra, D., & Rahmah, R. (2022). Uji Fisikokimia Sediaan Emulsi, Gel, Emulgel Ekstrak Etanol Goji

Berry (Lycium Barbarum L.). MEDFARM: Jurnal Farmasi Dan Kesehatan, 11(2), 219–228.

https://doi.org/10.48191/MEDFARM.V11I2.142

Ciszek, A. (2017). Variability of skin pH after the use of different collagen gels. Journal of Cosmetic

Dermatology, 16(4), 531–536. https://doi.org/10.1111/jocd.12303

Etemad-Parishanzadeh, O., Leven, Y., Kamps, L., Engels, T., & Gutmann, J. S. (2023). Acidic coating

- Textile finishing for the prevention of microbial growth. Melliand International.

https://www.scopus.com/pages/publications/85173792893?origin=scopusAI

Ezzat, R. Z., Stirrat, T., Nichols, E., & Ehrlich, A. (2025). Nutritional Supplements and Cosmetic

Formulations: A Review of Emerging Allergens. Dermatitis.

https://doi.org/10.1177/17103568251387141

FASKES

Jurnal Farmasi, Kesehatan dan Sains (FASKES)

Vol. 4, No. 1, (Juli 2026), P-ISSN : 3025-1508, E-ISSN : 2987-9841

Fatmawati Fatimah, S., Vanda Pertiwi, D., & Fitriyantoro, A. (2022). Uji Aktivitas Larvasida Emulsi

Minyak Atsiri Dari Daun Sirih Merah (Piper Crocatum) Terhadap Larva Aedes aegypti. Jurnal

Mitra Kesehatan, 4(2), 99–107. https://doi.org/10.47522/JMK.V4I2.136

Han, J., Sun, W., Chen, J., Yue, Z., Fang, W., Liu, X., Wang, J., & Wu, G. (2025). Design of

Coamorphous Systems for Flavonoid Components Coformed with Meglumine by Integrating

Theory-Model-Experiment Techniques. Molecular Pharmaceutics, 22(6), 3045–3060.

https://doi.org/10.1021/acs.molpharmaceut.4c01536

Harum Anggraini, P., Dwi Septiarini, A., Siska, T. W., Ilmu Kesehatan, F., Duta Bangsa, U., & Penulis,

K. (2021). Uji Daya Hambat Ekstrak Dan Fraksi N-Hekasan, Fraksi Etil Asetat, Fraksi Air Daun

Kersen (Muntingia Calabura L) Terhadap Bakteri Staphylococcus aureus ATCC 25923. Duta

Pharma Journal, 1(2), 8–19. https://doi.org/10.47701/DJP.V1I2.1209

Hayati, R., & Balqis, C. P. (2020). Formulasi Emulsi Topikal Ekstrak Umbi Bawang Putih (Allium

sativum L.) sebagai Insektisida Alami Pembasmi Kutu Rambut. PHARMACY: Jurnal Farmasi

Indonesia (Pharmaceutical Journal of Indonesia), 17(2), 304–316.

https://doi.org/10.30595/PHARMACY.V17I2.7372

Kaur, S., Panesar, P. S., Chopra, H. K., & Dilbaghi, N. (2024). Encapsulation of citrus polyphenols in

multi-phase nano-emulsion: Preservative potential, bio-accessibility and cytotoxicity studies. Food

Bioscience, 59. https://doi.org/10.1016/j.fbio.2024.103911

Kumar, V., Tanwar, N., Goel, M., Khan, M., Kumar, D., Singh, G., Mundlia, J., Khatri, N., & Kumar,

A. (2025). Antioxidants for Skin Health. Recent Advances in Food, Nutrition and Agriculture,

(3), 250–265. https://doi.org/10.2174/012772574X311177240710100118

Kupikowska-Stobba, B., Domagała, J., & Kasprzak, M. M. (2024). Critical Review of Techniques for

Food Emulsion Characterization. Applied Sciences (Switzerland), 14(3), 1069.

https://doi.org/10.3390/APP14031069/S1

M., A. S., Bodke, Y. D., & A., C. (2013). Antioxidant and in vivo anti-hyperglycemic activity of

muntingia calabura leaves extracts. Der Pharmacia Lettre.

https://www.scopus.com/pages/publications/84881513493?origin=scopusAI

Mitra Kesehatan, J., Fatmawati Fatimah, S., Vanda Pertiwi, D., & Fitriyantoro, A. (2022). Uji Aktivitas

Larvasida Emulsi Minyak Atsiri Dari Daun Sirih Merah (Piper Crocatum) Terhadap Larva Aedes

aegypti. Jurnal Mitra Kesehatan, 4(2), 99–107. https://doi.org/10.47522/JMK.V4I2.136

Murdiana, H. E., Putri, M. K., Rosita, M. E., Kristariyanto, Y. A., & Kurniawaty, A. Y. (2022). Optimasi

Formula Sediaan Krim Beras (Oryza Sativa L.) Tipe M/A Dengan Variasi Asam Stearat, Setil

Alkohol Dan Trietanolamin. Jurnal Farmamedika (Pharmamedica Journal), 7(2), 55–63.

https://doi.org/10.47219/ATH.V7I2.161

FASKES

Jurnal Farmasi, Kesehatan dan Sains (FASKES)

Vol. 4, No. 1, (Juli 2026), P-ISSN : 3025-1508, E-ISSN : 2987-9841

Nau’e, D. A. K., Yamlean, P. V. Y., & Mpila, D. A. (2020). Formulasi Sediaan Sabun Cair Kombinasi

Ekstrak Etanol Daun Kersen (Muntingia Calabura L.) Dan Daun Kemangi (Ocymum Basilicum

L.) Dan Uji Terhadap Bakteri Staphylococcus aureus. PHARMACON, 9(3), 404–412.

https://doi.org/10.35799/PHA.9.2020.30025

Nur, S., Alwani, M. F. N., Sami, F. J., Sapra, A., Aisyah, A. N., Indrisari, M., Nursamsiar, Yusuf, N.

A., & Aristianti. (2025). Transfersome-based delivery of Muntingia calabura fruit extract for antiaging applications. Biocatalysis and Agricultural Biotechnology, 66.

https://doi.org/10.1016/j.bcab.2025.103604

Nur, S., Sami, F. J., Sapra, A., Aisyah, A. N., Burhan, A., Megawati, Marwati, Yusuf, N. A., Mislia, &

Nursamsiar. (2024). Application box Behnken design for the optimum cream formula of M.

calabura fruit extract: In vitro and In vivo studies as an antiaging product. Research Journal of

Pharmacy and Technology, 17(11), 5325–5335. https://doi.org/10.52711/0974-360X.2024.00815

Prasad, A., Duchová, H., Manoharan, R. R., Rathi, D., & Pospíšil, P. (2023). Imaging and

Characterization of Oxidative Protein Modifications in Skin. International Journal of Molecular

Sciences, 24(4). https://doi.org/10.3390/ijms24043981

Pratiwi, T. B., Nurbaeti, S. N., Ropiqa, M., Fajriaty, I., Nugraha, F., & Kurniawan, H. (2023). Uji Sifat

Fisik pH Dan Viskositas Pada Emulsi Ekstrak Bintangur (Calophyllum soulattri Burm. F.).

Indonesian Journal of Pharmaceutical Education, 3(2), 2775–3670.

https://doi.org/10.37311/IJPE.V3I2.19466

Proksch, E. (2018). pH in nature, humans and skin. Journal of Dermatology, 45(9), 1044–1052.

https://doi.org/10.1111/1346-8138.14489

Raya, S. A., Saaid, I. M., Mohd Aji, A. Q., & A Razak, A. A. (2022). Investigation of the synergistic

effect of nonionic surfactants on emulsion resolution using response surface methodology. RSC

Advances, 12(48), 30952. https://doi.org/10.1039/D2RA04816G

Sharafan, M., Dziki, A., Malinowska, M. A., Sikora, E., & Szopa, A. (2025). Targeted Delivery

Strategies for Hydrophilic Phytochemicals. Applied Sciences (Switzerland), 15(13).

https://doi.org/10.3390/app15137101

Situmorang, R. F. R., Gurning, K., Kaban, V. E., Butar-Butar, M. J., & Perangin-Angin, S. A. B. (2022).

Determination of Total Phenolic Content, Analysis of Bioactive Compound Components, and

Antioxidant Activity of Ethyl Acetate Seri (Muntingia calabura L.) Leaves from North Sumatera

Province, Indonesia. Open Access Macedonian Journal of Medical Sciences, 10, 240–244.

https://doi.org/10.3889/oamjms.2022.8362

Tinrat, S., & Jiraprasertwong, O. (2023). An assessment of in vitro antibacterial, anti-biofilm,

antidiabetic and antioxidant activities of bioactive compounds from Muntingia calabura Linn.

FASKES

Jurnal Farmasi, Kesehatan dan Sains (FASKES)

Vol. 4, No. 1, (Juli 2026), P-ISSN : 3025-1508, E-ISSN : 2987-9841

leaves extracts. Pharmaceutical Sciences Asia, 50(4), 337–346.

https://doi.org/10.29090/psa.2023.04.23.922

Tran, T. P. A., Tran, T. T. V., Pham, T. L., & Phan, T. K. V. (2024). Potential use of PolyphenolEnriched Extract from Moringa oleifera Leaves as an Active Ingredient in Sunscreen. Natural and

Life Sciences Communications, 23(2). https://doi.org/10.12982/NLSC.2024.016

Tungadi, R., Paneo, M. A., & Nurkamiden, F. (2024). Pengembangan Teknik Matriks Patch Alpha

Arbutin Berbasis Nanoemulsi dan Uji Permeasi secara In Vitro. Jurnal Farmasi Teknologi Sediaan

Dan Kosmetika, 1(2), 53–63. https://doi.org/10.70075/JFTSK.V1I2.52

Wang, J., Ke, J., Wu, X., & Yan, Y. (2022). Astragaloside prevents UV-induced keratinocyte injury by

regulating TLR4/NF-κB pathway. Journal of Cosmetic Dermatology, 21(3), 1163–1170.

https://doi.org/10.1111/jocd.14174

Wulandari, F., Syaputri, F. N., & Jannah, N. R. (2022, July). Garuda - Garba Rujukan Digital.

https://garuda.kemdiktisaintek.go.id/documents/detail/2863168

Yu, J., Wang, Y., Li, D., & Wang, L. jun. (2022). Freeze-thaw stability and rheological properties of

soy protein isolate emulsion gels induced by NaCl. Food Hydrocolloids, 123.

https://doi.org/10.1016/J.FOODHYD.2021.107113

Zakaria, Z. A., Sani, M. H. M., Cheema, M. S., Kader, A. A., Kek, T. L., & Salleh, M. Z. (2014).

Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of

the possible mechanisms. BMC Complementary and Alternative Medicine, 14, 63.

https://doi.org/10.1186/1472-6882-14-63

Zhao, X. lei, Bao, Y. hong, Guo, Y., Luo, J. yuan, Jiang, S. long, & Yang, X. (2022). Effect of phenolic

compounds and hydroxyl content on the physicochemical properties of pine nut oil Pickering

emulsions. Journal of the Science of Food and Agriculture, 102(13), 5814–5825.

https://doi.org/10.1002/jsfa.11931

Downloads

Published

19.07.2026
Abstract View: 4, PDF Download: 2