Studi Molecular Docking Senyawa Ircinianin Terhadap Reseptor Sodium-Glukose Co-Transporter 2 (SGLT-2)

dwi syah fitra ramadhan; Ratnasari Dewi; Ismail  Ibrahim; Dwi Rachmawati Daswi; Nurisyah Nurisyah; Asyhari Asyikin; Tajuddin Abdullah

doi:10.32665/faskes.v2i2.3514

Authors

dwi syah fitra ramadhan Poltekkes Kemenkes Makassar
Ratnasari Dewi Jurusan Farmasi, Poltekkes Kemenkes Makassar
Ismail Ibrahim Jurusan Farmasi, Poltekkes Kemenkes Makassar
Dwi Rachmawati Daswi Jurusan Farmasi, Poltekkes Kemenkes Makassar
Nurisyah Nurisyah Jurusan Farmasi, Poltekkes Kemenkes Makassar
Asyhari Asyikin Jurusan Farmasi, Poltekkes Kemenkes Makassar
Tajuddin Abdullah Jurusan Farmasi, Poltekkes Kemenkes Makassar

DOI:

https://doi.org/10.32665/faskes.v2i2.3514

Keywords:

Ircinianin, SGLT-2, molecular docking

Abstract

Latar Belakang: Sodium-glucose cotransporter 2 (SGLT-2) merupakan target potensial dalam pengobatan diabetes tipe 2, dengan inhibitor SGLT-2 yang bekerja menghambat reabsorpsi glukosa di ginjal. Penelitian ini bertujuan untuk mengevaluasi potensi ircinianin, senyawa alami yang diisolasi dari spons Ircinia sp., sebagai inhibitor SGLT-2 menggunakan pendekatan molecular docking. Tujuan: Penelitian ini bertujuan untuk menganalisis interaksi antara ircinianin dan protein SGLT-2 serta mengevaluasi potensi penghambatan ircinianin terhadap reseptor SGLT-2. Metode: Metode yang digunakan adalah molecular docking dengan perangkat lunak AutoDock4. Prosedur dilakukan dengan docking ligan pada situs aktif SGLT-2. Ligan didocking dengan 100 iterasi untuk memperoleh konformasi ikatan yang optimal. Interaksi dianalisis berdasarkan energi ikatan dan visualisasi dilakukan menggunakan Discovery Studio. Hasil: Ircinianin menunjukkan energi ikatan sebesar -10,76 kcal/mol, sedikit lebih tinggi dibandingkan native ligand (-11,46 kcal/mol). Ircinianin membentuk dua ikatan hidrogen dengan residu PHE:98 dan TRP:291. Kesimpulan dan Saran: Ircinianin memiliki potensi sebagai inhibitor SGLT-2, meskipun ikatan hidrogennya lebih sedikit dibandingkan ligan asli. Penelitian lebih lanjut diperlukan untuk mengeksplorasi potensi terapeutik ircinianin dalam pengobatan diabetes tipe 2.

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